Science & Research
Else Toddler formula contains almond butter and buckwheat. While these are not common allergens, healthcare professionals should be aware of potential cross-allergenicity related to these ingredients. Else Toddler formula is free of soy, gluten, and dairy allergens. Below are some suggested readings for healthcare professionals for more information related to these topics:
C D Salpietro, S Gangemi, S Briuglia, A Meo, M V Merlino, G Muscolino, G Bisignano, D Trombetta, A Saija. The almond milk: a new approach to the management of cow-milk allergy/intolerance in infants. Minerva Pediatrica 2005;57:173-80
This randomized study conducted in 52 infants with documented CMI/CMA tested the safety and efficacy of a new almond-based milk comparing soy-based formula and extensively hydrolyzed formula. The main efficacy outcomes were the improvement in clinical symptoms and the decrease in serum levels of soluble CD30 (a potential marker of atopic disorders,sCD30). The authors find that elimination of milk proteins and the supplementation with milk protein free formula resulted in considerable improvement of clinical manifestations within 5-12 days in all cases examined. No difference in growth rates between the groups . in the soy-based formula and extensively
Baker MG, Kattan JD. Review of 400 consecutive oral food challenges to almond. Annal Allergy Asthma Immunol. 2019;122(2):189-92. Due to the high rate of false-positive skin-prick tests for almond allergy, it is important to explore the safety of oral food challenges in those with suspected sensitization. Authors found a 94% (375/400) passed the oral food challenge, quantified by sIgE and skin prick wheal size, for those with suspected almond allergy, 4% (16/400) failed the oral food challenge, and 2% (9/400) had indeterminant reactions. This study found that anaphylaxis requiring epinephrine was rare (0.005%; 2/400 oral food challenge participants), and that pruritis was the most common symptom among those who experienced a reaction. Since almonds can serve as a popular source of nutrients for dairy-free or plant-based protein foods, oral food challenge may be feasible to help minimize potentially unnecessary avoidance of almonds.
Sammut D, Dennison P, Venter C, Kurukulaaratchy RJ. Buckwheat allergy: a potential problem in 21st century Britain. BMJ Case Reports. 2011;10.1136/bcr.09.2011.4882. These authors summarize background of buckwheat as a potential food allergen, noting that is rare outside of Japan or other Asian countries. Since it is taxonomically unrelated to wheat, it is suitable for those requiring a gluten-free diet. The most common reactions include angioedema, anaphylaxis, uticaria, asthma/rhinitis, and GI disturbance. Authors also present the first two adult case reports of buckwheat sensitization in the United Kingdom, confirmed by sIgE and skin-prick test and identified upon post-prandial IgE-mediated reactions.
Badiu I, Olivieri E, Montagni M, et al. Italian study on buckwheat allergy: prevalence and clinical features of buckwheat-sensitized patients in Italy. Int J Immunol Pharmacol. 2013;26(3):801-806. Due to limited data on prevalence of buckwheat allergy in non-Asian countries, these authors conducted an epidemiological study across 18 Italian allergy clinics. Of included patients, 61.3% (1198/1954) were atopic and 3.6% (70/1954) had a positive skin-prick test for buckwheat. The authors found differences in mean buckwheat allergy prevalence across regions, with sensitization being more common in northern Italy.
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