Food Allergy/Intolerance and Diagnosis

This article highlights defining features and symptoms of food protein-induced enterocolitis (FPIES) and identified by an international expert consensus group.  It provides empiric guidelines for weaning food for infants with emphasis on practices that optimize development and minimize adverse risks.  Notably, this expert panel highlights that no studies have identified threshold doses of trigger foods for FPIES, it is thought to be high and therefore it is not indicated to routinely avoid products with precautionary statements. Experts also recommend use of a hypoallergenic formula in formula-fed infants with cow’s milk induced FPIES or those no longer able to be breastfed. Ultimately, experts identify best practices for early management of FPIES.


Nowak-Węgrzyn A, Chehade M, Groetch ME, et al. International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol. 2017;139(4):1111-26.